1176 67 16242 5 54288 document 16242 Data.zip application/zip 6c795e093cff17eff0d9ab3810740680 MD5 5361382 2022-07-26 15:30:13 https://researchdata.bath.ac.uk/1176/1/Data.zip 1176 1 1 application/zip other en public cc_by

Data.zip

data archive 11301 disk0/00/00/11/76 2023-05-24 09:06:39 2024-07-18 12:32:05 2023-05-24 09:06:39 data_collection show Turner Joe jt2156@bath.ac.uk 0000-0002-9476-6917 University of Bath TRUE Laabei Maisem M.Laabei@bath.ac.uk 0000-0002-8425-3704 University of Bath FALSE Li Shuxian sl2746@bath.ac.uk University of Bath FALSE Estrela Pedro P.Estrela@bath.ac.uk 0000-0001-6956-1146 University of Bath FALSE Leese Hannah H.S.Leese@bath.ac.uk 0000-0003-4523-3804 University of Bath TRUE DataCollector Turner Joe jt2156@bath.ac.uk 0000-0002-9476-6917 University of Bath DataCollector Laabei Maisem M.Laabei@bath.ac.uk 0000-0002-8425-3704 University of Bath DataCollector Li Shuxian sl2746@bath.ac.uk University of Bath Supervisor Estrela Pedro P.Estrela@bath.ac.uk 0000-0001-6956-1146 University of Bath Supervisor Leese Hannah H.S.Leese@bath.ac.uk 0000-0003-4523-3804 University of Bath BV0030 CM0060 dept_chem_eng dept_elec_eng dept_bio This dataset pertains to a study involving the use of 3D printed microneedles (MNs) to form hydrogel-forming MNs (HFMs) for the delivery of antibiotics (amoxicillin and vancomycin) transdermally. It includes: - the HFMs ability to swell in fluids over time rapidly and take up drugs in solution as a result (including characterisation of the HFMs and drug loaded-HFMs); - the mechanical properties and skin penetration of both HFMs and Drug-loaded HFMs; - the drug release profiles of the drug-loaded HFMs and how to control the release; - the antimicrobial properties of the antibiotic HFMs against susceptible bacteria. The data provides a suggestion towards the use of HFMs for the effective transdermal delivery of antibiotics, towards reducing the rate of antimicrobial resistance increase. 2023-05-23 University of Bath public RightsHolder University of Bath Engineering and Physical Sciences Research Council https://doi.org/10.13039/501100000266 EP/V010859/1 Minimally Invasive Molecularly Imprinted Conductive Nanoneedle Sensors Royal Society https://doi.org/10.13039/501100000288 RGS\R1\201185 Molecularly Imprinted Conductive Microneedles Abbott Diabetes Care https://doi.org/10.13039/100011946 2283996 Studentship - Detect, treat and tell: Skin patches to sense infection and indicate recovery cent_c3bio Antimicrobial Properties: Disk Diffusion Assays using E.coli and S.aureus. Samples incuated for 24 hours. Optically monitored the area of inhibition surrounding the HFMs. Data provided are images, analysed using ImageJ with data saved in text file. Drug Release: Drug loaded HFMs were submerged in PBS. PBS samples were taken over time and UV-Vis analysis was used to calculate the concentration of drug that has been release. Data is in the form of Excel document. Mechanical properties: HFMs were tested on a DMA up to 10 newtons. Data is proved in the form of Excel document. Skin Penetration: HFMs were placed on porcine skin and a known force was applied and the resultant skin pores were optically imaged. Data is in the form of images. Swelling: HFMs were submerged in PBS. The mass of the HFMs was taken at various time points. The data provided is in the form of an Excel file. Raw data and data analysis can been found in the respective files. The data is provided in MS Excel format. en 1 10.15125/BATH-01176 https://doi.org/10.1016/j.bioadv.2023.213467 pub open Dataset