A multi-disciplinary team-based classroom exercise for small molecule drug discovery

1306 35 17313 2 62298 document 17313 List of files.pdf application/pdf 52e00358506e4e54a558a636d59a6a16 MD5 153643 2023-08-07 15:50:53 https://researchdata.bath.ac.uk/1306/7/List%20of%20files.pdf 1306 7 7 application/pdf other List of files included in the dataset. en public cc_by_sa

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http://eprints.org/relation/isVersionOf https://researchdata.bath.ac.uk/id/document/17313 http://eprints.org/relation/isVolatileVersionOf https://researchdata.bath.ac.uk/id/document/17313 http://eprints.org/relation/issmallThumbnailVersionOf https://researchdata.bath.ac.uk/id/document/17313 archive 9709 disk0/00/00/13/06 2023-08-09 14:54:26 2024-05-14 13:12:57 2023-08-09 14:54:26 data_collection show Dodson Charlotte C.A.Dodson@bath.ac.uk 0000-0002-8403-726X University of Bath TRUE Flower Steve S.E.Flower@bath.ac.uk 0000-0003-2659-3118 University of Bath FALSE Thomas Mark m.thomas@bath.ac.uk 0000-0002-7648-2400 University of Bath FALSE A multi-disciplinary team-based classroom exercise for small molecule drug discovery BY0020 BY0130 CM0020 dept_health dept_chem dept_life_sci Drug discovery, Virtual drug discovery, Dry Lab, Teaching Resource, National Teaching Repository, Master's Tools, Final year undergraduate, problem-solving skills, interdisciplinary research problems, interdisciplinary study, Sharing practice Industrial drug discovery teams encompass scientists from multiple specialities and require participants to communicate effectively across disciplinary boundaries. In this resource we present an undergraduate or graduate classroom simulation of this environment. Over a series of five workshops, student teams of mixed scientific backgrounds perform five iterations of the chemistry cycle of small molecule drug discovery. Students analyze physicochemical, structural and (fictional) assay data, and use these to design new compounds for testing. Simulated assay results are returned to students who use the information in the design of subsequent compounds. After workshop 5, each team submits a single lead compound, supported by a potential synthetic route, a portfolio of assay data and logical scientific decision-making. Our exercise provides students with opportunities for hands-on student-responsive data handing, team-building, and technical knowledge acquisition – all within an industrially relevant scientific scenario. 2023-07-25 National Teaching Repository public RightsHolder University of Bath University of Bath https://doi.org/10.13039/501100000835 https://doi.org/10.1021/acs.jchemed.3c00066 en 3 10.25416/NTR.21908502 https://doi.org/10.1021/acs.jchemed.3c00066 pub open Dataset 1352