Dataset for “Ketogenic diet but not free-sugar restriction alters glucose tolerance, lipid metabolism, peripheral tissue phenotype, and gut microbiome: RCT”

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AH 12-week CHO intervention_registered reports_v3 copy.pdf

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Participant information sheet v2.0 13.9.18.pdf

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Consent form v2.0 20.06.18.pdf

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Parallel RCT Master data_03.07.2024.xlsx

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http://eprints.org/relation/isVersionOf https://researchdata.bath.ac.uk/id/document/18203 http://eprints.org/relation/isVolatileVersionOf https://researchdata.bath.ac.uk/id/document/18203 http://eprints.org/relation/isIndexCodesVersionOf https://researchdata.bath.ac.uk/id/document/18203 archive 5722 disk0/00/00/13/66 2024-08-05 15:13:04 2025-04-28 12:41:59 2024-08-05 15:13:04 data_collection show Gonzalez Javier j.t.gonzalez@bath.ac.uk 0000-0002-9939-0074 University of Bath TRUE Dataset for “Ketogenic diet but not free-sugar restriction alters glucose tolerance, lipid metabolism, peripheral tissue phenotype, and gut microbiome: RCT” EP0010 dept_health Energy balance, Metabolism, Ketogenic, Sugar, Diet, Physical activity, Body fat, Energy intake, Lipoprotein The dataset includes demographic data of participants (n=60) randomised to one of three groups: 1. CONTROL (moderate sugar) - reflecting the composition of a typical European diet; 2. Low sugar - the same composition of a typical European diet but with <5% energy intake from sugar; 3. Low carbohydrate - low carbohydrate diet with <5% energy intake from sugar, replacing carbohydrate energy with fat. All laboratory trials took place at the University of Bath. Participants consumed these diets for period of 12 weeks, with laboratory visits at baseline, at week 4, and at week 12. The types of data that were collected during the trials are as follows: - Height; - Body mass; - Body composition (by Dual-energy x-ray absorptiometry); - Resting metabolic rate; - Postprandial substrate oxidation; - Exercise metabolism; - Physical activity energy expenditure; - Fasting and postprandial concentrations of circulating metabolites (e.g., glucose, lactate triacylglycerol) and hormones (e.g. insulin, C-peptide); - Nuclear magnetic resonance spectroscopy measures of plasma (e.g., lipoprotein size and particle number); - Skeletal muscle protein levels; - Adipose tissue mRNA levels; - Fasting haematology (e.g., white blood cell count, haematocrit, haemoglobin concentration); - Urinary acetoacetate concentrations; - Self-reported energy intake; - Visual analogue scales for appetite and mood; - Continuous glucose monitoring. 2024-08-05 University of Bath public RightsHolder University of Bath Rank Prize Funds PACSI Physical Activity and the Role of Sugar Intake Cosun Nutrition Center PACSI Physical Activity and the Role of Sugar Intake University of Bath https://doi.org/10.13039/501100000835 PACSI Physical Activity and the Role of Sugar Intake Ian Tarr PACSI Physical Activity and the Role of Sugar Intake Medical Research Council (MRC) https://doi.org/10.13039/501100000265 MR/P002927/1 Role of Rab3 in Peripheral Tissue Insulin Resistance British Heart Foundation (BHF) https://doi.org/10.13039/501100000274 FS/15/56/31645 Fellowship British Heart Foundation (BHF) https://doi.org/10.13039/501100000274 FS/SBSRF/21/31013 Fellowship cent_cnem https://clinicaltrials.gov/study/NCT03574987 en 1 10.15125/BATH-01366 https://doi.org/10.1016/j.xcrm.2024.101667 pub open Dataset