The dataset presented herewith is that of a research paper entitled “Sodium alginate/cuprous oxide composite materials with antibacterial properties: A preliminary study revealing the counteracting effects of oligosaccharides in the matrix”, authored by Reeba Thomas, Fengyi Wang, Wipa Suginta, Chien-Yi Chang, Fengwei Xie. In this study, different hydrogels based on sodium alginate (SA) included with chitin or chitosan oligosaccharides (NACOS or COS) and cuprous oxide (Cu₂O) nanoparticles were prepared and their antimicrobial properties were assessed. The details of this research can be read from the paper.