1497 58 18842 4 74989 document 18842 WGM-DNA-dataset.zip application/zip 8af005e0d9fb6aa2e78dc724735160d9 MD5 20558863 2025-03-04 15:21:16 https://researchdata.bath.ac.uk/1497/1/WGM-DNA-dataset.zip 1497 1 1 application/zip other This zipped file contains processed data from figures 1-5 of the associated manuscript. en public cc_by

WGM-DNA-dataset.zip

data archive 15314 disk0/00/00/14/97 2025-03-06 15:29:22 2025-03-17 12:21:45 2025-03-06 15:29:22 data_collection show Caixeiro Soraya scc201@bath.ac.uk 0000-0003-4605-957X University of Bath TRUE Dörrenhaus Robert drobert1@uni-koeln.de 0009-0006-4685-9939 University of Cologne FALSE Popczyk Anna anna.popczyk@uni-koeln.de 0000-0001-6291-6928 University of Cologne FALSE Schubert Marcel marcel.schubert@uni-koeln.de 0000-0002-8739-4852 University of Cologne FALSE Kath-Schorr Stephanie skathsch@uni-koeln.de 0000-0002-5180-360X University of Cologne FALSE Gather Malte C. mcg6@st-andrews.ac.uk 0000-0002-4857-5562 University of St Andrews; University of Cologne FALSE BY0020 GE0010 HH0020 dept_physics Nucleic acid sensing is crucial for advancing diagnostics, therapeutic monitoring and molecular biology research, by enabling the precise identification of DNA and RNA interactions. Here, we present an innovative sensing platform based on DNA-functionalized whispering gallery mode (WGM) microlasers. By correlating spectral shifts in laser emission to changes in refractive index, we demonstrate real-time detection of DNA hybridization and structural changes. The addition of gold nanoparticles to the DNA strands significantly enhances sensitivity, and labelling exclusively the sensing strand or a hairpin strand eliminates the need for secondary labelling of the target strand. We further show that ionic strength influences DNA compactness, and we introduce a hairpin-based system as a dual-purpose sensor and con-trolled release mechanism for potential drug delivery. This versatile WGM-based platform offers promise for sequence-specific nucleic acid sensing, multiplexed detection, and in vivo applications in diagnostics and cellular research. This dataset includes the data from Figures 1-5 of the associated paper. It is organised into folders by figure number for easy navigation, with filenames indicating the corresponding figure and identifying letters (e.g., a, b, c, d). For details on how the data was collected refer to publication and its supplementary information. 2025-03-04 University of Bath public Other University of Bath Other University of St Andrews Other University of Cologne Alexander von Humboldt Foundation https://doi.org/10.13039/100005156 Alexander von Humboldt professorship to M.C.G cent_photon The methodology can be found in the associated paper. https://doi.org/10.48550/arXiv.2502.13664 en 1 10.15125/BATH-01497 https://doi.org/10.1021/acs.nanolett.5c00078 pub open Dataset