Dataset for "The impact of exercise intensity on whole body and adipose tissue metabolism during energy restriction in sedentary overweight men and postmenopausal women"

313 27 5400 2 12931 document 5400 Repository_data.xlsx application/vnd.openxmlformats-officedocument.spreadsheetml.sheet 8924120800ad73f7a4986254bf380af3 MD5 57754 2016-10-28 09:51:46 https://researchdata.bath.ac.uk/313/1/Repository_data.xlsx 313 1 1 application/vnd.openxmlformats-officedocument.spreadsheetml.sheet other en public cc_by

Repository_data.xlsx

data 5401 2 12934 document 5401 README_FILE_FOR_ARCHIVE_PR_JPW.docx application/vnd.openxmlformats-officedocument.wordprocessingml.document 0ae4e52d457c4b5f14c5118acb671e9e MD5 16350 2016-10-28 09:52:12 https://researchdata.bath.ac.uk/313/2/README_FILE_FOR_ARCHIVE_PR_JPW.docx 313 2 2 application/vnd.openxmlformats-officedocument.wordprocessingml.document other en public cc_by

README_FILE_FOR_ARCHIVE_PR_JPW.docx

documentation 5402 1 12936 document 5402 indexcodes.txt text/plain 91c771c03da0eea36aa327050a88244b MD5 2734 2016-10-28 09:52:18 https://researchdata.bath.ac.uk/313/3/indexcodes.txt 313 3 3 text/plain other Generate index codes conversion from other to indexcodes en public

indexcodes.txt

http://eprints.org/relation/isVersionOf https://researchdata.bath.ac.uk/id/document/5401 http://eprints.org/relation/isVolatileVersionOf https://researchdata.bath.ac.uk/id/document/5401 http://eprints.org/relation/isIndexCodesVersionOf https://researchdata.bath.ac.uk/id/document/5401 archive 1188 disk0/00/00/03/13 2016-11-01 15:34:22 2024-09-19 11:24:21 2016-11-01 15:34:22 data_collection show Walhin Jean-Philippe j.walhin@bath.ac.uk 0000-0002-8103-5541 University of Bath TRUE Researcher Thompson Dylan D.Thompson@bath.ac.uk 0000-0002-6312-1518 University of Bath Researcher Betts James J.Betts@bath.ac.uk 0000-0002-9129-5777 University of Bath Researcher Dixon Natalie N.C.Dixon@bath.ac.uk University of Bath Dataset for "The impact of exercise intensity on whole body and adipose tissue metabolism during energy restriction in sedentary overweight men and postmenopausal women" dept_health Dataset relating to trial registration ISRCTN86152135 Objective: To establish whether vigorous-intensity exercise offers additional adipose-related health benefits and metabolic improvements compared to energy-matched moderate-intensity exercise. Methods: Thirty-eight sedentary overweight men (n=24) and postmenopausal women (n=14) aged 52 ± 5 years (mean ± SD) were prescribed a 3-week energy deficit (29302 kJ∙week-1) achieved by increased isocaloric moderate or vigorous-intensity exercise (+8372 kJ∙week-1) and simultaneous restricted energy intake (-20930 kJ∙week-1). Participants were randomly assigned to either an energy-matched vigorous (VIG; n=18) or moderate (MOD; n=20) intensity exercise group (five times per week at 70% or 50% maximal oxygen uptake, respectively). At baseline and follow-up, fasted blood samples and abdominal subcutaneous adipose tissue biopsies were obtained and oral glucose tolerance tests conducted. Results: Body mass was reduced similarly in both groups (∆ 2.4 ± 1.1 kg and ∆ 2.4 ± 1.4 kg, respectively, P<0.05). Insulinaemic responses to a standard glucose load decreased similarly at follow-up relative to baseline in VIG (∆ 8.6 ± 15.4 nmol.120min.l-1) and MOD (∆ 5.4 ± 8.5 nmol.120min.l-1; P<0.05). Expression of SREBP-1c and FAS in adipose tissue was significantly down-regulated whereas expression of PDK4 and HSL was significantly up-regulated in both groups (P<0.05). Conclusions: When energy expenditure and energy deficit are matched, vigorous or moderate-intensity exercise combined with energy restriction provide broadly similar (positive) changes in metabolic control and adipose tissue gene expression. 2016 University of Bath public RightsHolder University of Bath University of Bath https://doi.org/10.13039/501100000835 https://doi.org/10.1186/ISRCTN86152135 en 1 10.15125/BATH-00313 https://doi.org/10.14814/phy2.13026 pub https://doi.org/10.1186/ISRCTN86152135 website open