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    <title>Dataset for &apos;Pre-Exercise Breakfast Ingestion versus Extended Overnight Fasting Increases Postprandial Glucose Flux after Exercise in Healthy Men: Pre-exercise feeding and postprandial glucose flux&apos;</title>
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    <keywords>Breakfast, Exercise, Insulin sensitivity, Glycemia, Metabolism</keywords>
    <abstract>The aim of this study was to characterise postprandial glucose flux after exercise in the fed versus overnight fasted-state and to investigate potential underlying mechanisms. In a randomized order, twelve men underwent breakfast-rest (BR; 3 h semi-recumbent), breakfast-exercise (BE; 2 h semi-recumbent before 60-min of cycling (50% peak power output) and overnight fasted-exercise (FE; as per BE omitting breakfast) trials. An oral glucose tolerance test (OGTT) was completed post-exercise (post-rest on BR). Dual stable isotope tracers ([U-13C] glucose ingestion and [6,6-2H2] glucose infusion) and muscle biopsies were combined to assess postprandial plasma glucose kinetics and intramuscular signaling, respectively. Plasma intestinal fatty acid binding (I-FABP) concentrations were determined as a marker of intestinal damage. The results from this study showed that consuming breakfast before exercise increases post-exercise postprandial plasma glucose disposal, which is offset (primarily) by increased appearance rates of orally-ingested glucose. Therefore, metabolic responses to fed-state exercise cannot be readily inferred from studies conducted in a fasted state.</abstract>
    <date>2019-02-27</date>
    <publisher>University of Bath</publisher>
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        <funder_name>Medical Research Council</funder_name>
        <funder_id>https://doi.org/10.13039/501100000265</funder_id>
        <grant_id>MR/P002927/1</grant_id>
        <project_name>Role of Rab3 in Peripheral Tissue Insulin Resistance</project_name>
      </item>
      <item>
        <funder_name>Rank Prize Funds</funder_name>
        <project_name>Fellowship for Javier Gonzalez - Understanding the Influence of Pre-Exercise Nutrition on PostPrandial Carbohydrate Metabolism and Energy Balance</project_name>
      </item>
      <item>
        <funder_name>European Society for Clinical Nutrition and Metabolism</funder_name>
        <funder_id>https://doi.org/10.13039/501100007743</funder_id>
        <project_name>ESPEN Research Fellowship for Javier Gonzalez - Using the Paradoxical Second-Meal Phenomenon to Gain Insight into the Molecular and Metabolic Regulation of Whole-Body Glucose Metabolism</project_name>
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    <collection_method>Supplementary (individual participant) data are included in this data set for reported outcome measures.</collection_method>
    <language>en</language>
    <version>1</version>
    <doi>10.15125/BATH-00608</doi>
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        <link>https://doi.org/10.1152/ajpendo.00163.2018</link>
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