Dataset for "Lipid metabolism links nutrient-exercise timing to insulin sensitivity in overweight men"

672 50 11401 3 33192 document 11401 Data.xlsx application/vnd.openxmlformats-officedocument.spreadsheetml.sheet 9c7faf4d79f6b66327b82eb8327668fc MD5 108191 2019-06-10 11:08:05 https://researchdata.bath.ac.uk/672/1/Data.xlsx 672 1 1 application/vnd.openxmlformats-officedocument.spreadsheetml.sheet other Supplementary (individual participant) data are included in this data set for reported outcome measures. en public cc_by

Data.xlsx

data 11417 2 33299 document 11417 Read_me_file_for_archive.docx application/vnd.openxmlformats-officedocument.wordprocessingml.document 6bda138d297a47d9cff2b89da35abc3b MD5 24106 2019-06-17 08:50:44 https://researchdata.bath.ac.uk/672/2/Read_me_file_for_archive.docx 672 2 2 application/vnd.openxmlformats-officedocument.wordprocessingml.document other This document contains information regarding the methods used to collect the data provided in the excel data sheet. en public cc_by

Read_me_file_for_archive.docx

documentation 11418 1 33304 document 11418 indexcodes.txt text/plain f18f24fecd2a9ae3d59a621fe1549b8d MD5 5632 2019-06-17 11:09:15 https://researchdata.bath.ac.uk/672/3/indexcodes.txt 672 3 3 text/plain other Generate index codes conversion from other to indexcodes en public

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http://eprints.org/relation/isVersionOf https://researchdata.bath.ac.uk/id/document/11417 http://eprints.org/relation/isVolatileVersionOf https://researchdata.bath.ac.uk/id/document/11417 http://eprints.org/relation/isIndexCodesVersionOf https://researchdata.bath.ac.uk/id/document/11417 11935 2 34751 document 11935 Supplementary_Materials_and_Tables.docx application/vnd.openxmlformats-officedocument.wordprocessingml.document 1abb7b6a5a6a53d0f87abbfde7c67dde MD5 34693 2019-09-25 14:20:16 https://researchdata.bath.ac.uk/672/4/Supplementary_Materials_and_Tables.docx 672 4 4 application/vnd.openxmlformats-officedocument.wordprocessingml.document other en public cc_by

Supplementary_Materials_and_Tables.docx

documentation 11936 1 34753 document 11936 indexcodes.txt text/plain 3f1fd10d1b2f346eb1a89bdb6e29b6c8 MD5 6997 2019-09-25 14:30:38 https://researchdata.bath.ac.uk/672/5/indexcodes.txt 672 5 5 text/plain other Generate index codes conversion from other to indexcodes en public

indexcodes.txt

http://eprints.org/relation/isVersionOf https://researchdata.bath.ac.uk/id/document/11935 http://eprints.org/relation/isVolatileVersionOf https://researchdata.bath.ac.uk/id/document/11935 http://eprints.org/relation/isIndexCodesVersionOf https://researchdata.bath.ac.uk/id/document/11935 archive 6522 disk0/00/00/06/72 2019-10-31 10:28:44 2024-07-15 10:59:10 2019-10-31 10:28:44 data_collection show Edinburgh Rob R.M.Edinburgh@bath.ac.uk 0000-0003-4263-3415 University of Bath TRUE Bradley Helen ~h.e.bradley@bham.ac.uk University of Birmingham FALSE Abdullah Nurul nfa425@bham.ac.uk 0000-0002-9816-629X University of Birmingham FALSE Robinson Scott slr247@bham.ac.uk University of Birmingham FALSE Chrzanowski-Smith Oliver O.J.Chrzanowski-Smith@bath.ac.uk 0000-0002-9004-321X University of Bath FALSE Walhin Jean-Philippe J.Walhin@bath.ac.uk 0000-0002-8103-5541 University of Bath FALSE Joanisse Sophie 0000-0001-9983-9401 University of Birmingham FALSE Manolopoulos Konstantinos 0000-0001-8890-6090 University of Birmingham FALSE Philp Andrew 0000-0003-3860-4136 Garvan Institute of Medical Research FALSE Hengist Aaron A.Hengist@bath.ac.uk 0000-0003-4573-7105 University of Bath FALSE Chabowski Adrian 0000-0002-7407-8156 Medical University of Białystok FALSE Brodsky Frances 0000-0002-1334-9258 University College London FALSE Koumanov Francoise F.Koumanov@bath.ac.uk 0000-0002-9029-3390 University of Bath FALSE Betts James J.Betts@bath.ac.uk 0000-0002-9129-5777 University of Bath FALSE Thompson Dylan D.Thompson@bath.ac.uk 0000-0002-6312-1518 University of Bath FALSE Wallis Gareth 0000-0002-1400-0859 University of Birmingham FALSE Gonzalez Javier J.T.Gonzalez@bath.ac.uk 0000-0002-9939-0074 University of Bath TRUE Dataset for "Lipid metabolism links nutrient-exercise timing to insulin sensitivity in overweight men" BY0020 BY0030 dept_health The aim of the present work was to assess the acute and chronic effects of manipulating nutrient-exercise timing on lipid metabolism, skeletal muscle adaptation, and oral glucose insulin sensitivity in overweight and obese men. This project comprised two experiments. We first assessed the acute metabolic and mRNA responses to manipulating nutrient-exercise timing (Acute Study), followed by a 6-week randomized controlled trial to assess the longer-term adaptations in response to nutrient-exercise timing (Training Study). We showed that in overweight/obese, but otherwise healthy men (mean±SD for age: 30 ± 10 years for acute study, 35 ± 9 years for training study and BMI: 30.2±3.5 kg/m-2 for acute study, 30.9±4.5 kg/m-2 for training study) a single exercise bout before versus after nutrient provision increased lipid utilization at the whole-body level, but also in both type I (p<0.01) and type II muscle fibers (p=0.02). We then used a 6-week intervention to show sustained, 2-fold increases in lipid utilization with exercise training before versus after nutrient provision (p<0.01). An oral glucose-derived estimate of peripheral insulin sensitivity (OGIS index) increased when training was performed before versus after nutrient provision (25±38 vs -21±32 mL/min/m-2; p=0.01) and this was associated with increased lipid utilization during exercise (r=0.50, p=0.02). Regular exercise prior to nutrient provision augmented remodelling of skeletal muscle phospholipids and muscle expression of the glucose transport protein GLUT4 (p<0.05). These responses were observed despite similar changes in body mass, waist-to-hip ratio, and oxidative capacity. Therefore: 1) experiments investigating exercise training and metabolic health need to control for nutrient-exercise timing; 2) exercise performed before versus after nutrient intake may exert beneficial effects on lipid utilization and oral glucose insulin sensitivity. 2019-10-19 University of Bath public RightsHolder University of Bath Physiological Society https://doi.org/10.13039/501100000674 Can Exercise in the Fasted State Unlock Metabolic Health Benefits for Overweight and Obese Individuals Allen Foundation https://doi.org/10.13039/100008796 Medical Research Council https://doi.org/10.13039/501100000265 MR/P002927/1 Role of Rab3 in Peripheral Tissue Insulin Resistance Medical Research Council https://doi.org/10.13039/501100000265 MR/S008144/1 Regulation of Human Glucose Homeostasis by the Novel CHC22 Clathrin Isoform Rank Prize Funds Fellowship for Javier Gonzalez - Understanding the Influence of Pre-Exercise Nutrition on PostPrandial Carbohydrate Metabolism and Energy Balance European Society for Clinical Nutrition and Metabolism https://doi.org/10.13039/501100007743 ESPEN Research Fellowship for Javier Gonzalez - Using the Paradoxical Second-Meal Phenomenon to Gain Insight into the Molecular and Metabolic Regulation of Whole-Body Glucose Metabolism Supplementary (individual participant) data are included in this data set for reported outcome measures. Detailed data collection methods are included in the documentation (readme) file. en 1 10.15125/BATH-00672 https://doi.org/10.1210/clinem/dgz104 pub open