These files contain the raw expression (in FPKM) data from RNA sequencing data sets generated from adipose tissue samples collected before and at the end of a long-term head-down tilt bed rest study in healthy young males (ref: AO-13-BR). These files are also RNA sequencing data sets generated from adipose tissue and skeletal muscle samples collected from healthy young and older adults in a cross-sectional study (ref: 16/SW/0003).