Spent coffee grounds (SCGs) have been extensively investigated as a feedstock to produce fuels, specialty chemicals and materials. Whilst a few reports have used cascade processes to generate several products from SCG, this work takes the novel approach of using integrated subcritical water extraction (SWE) and hydrothermal carbonisation (HTC) to derive three products: a bioactive extract, a protein isolate (SCG PI) and solid fuel. SWE and HTC processes were optimized producing an antioxidant rich extract, with the chlorogenic acid (CGA) content and antioxidant activity determined. This work goes towards the complete utilisation of SCGs within a biorefinery, highlighting the potential of subcritical water processing to produce commercially viable products across the value chain. In this dataset, the raw concentrations of CGA and all other antioxidants, the yields and proximate analysis of the HTC reactions and the yields of the SWE extractions are all presented.