Dataset for "Florescent Styrene Maleic Acid Copolymer to Facilitate Membrane Protein Studies in Lipid Nanodiscs" Contents: Main Article: Figure 2: Raw DLS traces for SMA aggregates at 25 and 55oC, Nanodiscs, and Nanodisc+Gramicidin samples used to produce Figure 2. Figure 3: Figure 3a: Raw and normalised excitation and emission data for various copolymers and gramicidin Figure 3b: Raw and analysed (I/I0) data showing increased emission upon interaction of fluorescent SMA with DMPC vesicles. Figure 3c: Raw and normalised emission data for various Nanodisc+Gramicidin samples, highlight FRET occurrence in PY-SMA discs. ESI: Figure S1 (FTIR) FTIR for various copolymers pre and post hydrolysis. Figure S2 (H1 NMR) H1 NMR spectra for SMAnh-VA0.01 Figure S3 (C13 NMR) C13 NMR spectra for SMAnh-2000 and SMAnh-R Figure 4S / Table S2 (GPC) Raw and analysed GPC chromatograms for all copolymers presented. Figure S5 (SAXS) Raw SAXS data for SMA-2000 and SMA-VA0.1 DMPC nanodisc samples. Figure S7 (Fluorescence Spectra) Various excitation and emission data for SMAnh-VA0.1 and SMAnh-VA0.01 and SMAnh-R. Figure S8 (Fluorescence Spectra) Emission spectra for SMA-VA0.01 and SMA-PY0.01 copolymers at various temperatures, and for nanodiscs formed from the same copolymers, highlighting increased emission upon interaction with DMPC vesicles.