Dataset for "Influence of Block Microstructure on the Interaction of Styrene- Maleic Acid Copolymer Aggregates and Lipid Nanodiscs" Note: Raw SANS data (DOI: 10.5286/ISIS.E.RB2010215) collected on the SANS2D instrument can be found in the ISIS-ICAT system at https://data.isis.stfc.ac.uk/doi/INVESTIGATION/111242883/. Contents: Main Article: Table 1 (GPC Analysis): Analysed GPC data with extracted Mn values for SMAnh copolymers. Figure 4 (GPC Traces): Figure 4a: Raw GPC traces for Fwd and SMAnh 2000. Figure 4b: Raw GPC traces for hydrogenated and deuterated Fwd, Rev and Tri partial, Sty, and full SMAnh copolymer variants. Figure 4c: Raw GPC traces for partial, Tri Sty, and full Tri SMAnh copolymers. Figure 5 (DLS aggregates): Averaging of aggregates diameter and PDI values from DLS traces. Figure 7 (UV-vis Formation Kinetics) Raw time resolved UV-vis data of incubation of copolymer variants with DMPC vesicle and Ecoli membrane suspensions at 37 oC. Copolymer injection at 310 s. Figure 8 (DLS nanodsics) Averaging of nanodisc diameter and PDI values from DLS traces. ESI: Figure S1 (1H NMR) 1H NMR Spectra of Fwd SMAnh, Rev SMAnh and Tri SMAnh. Figure S2 (13C NMR) 13C NMR spectra of Fwd SMAnh, Rev SMAnh, Tri SMAnh and SMAnh 2000. Figure S3 (FTIR): Figure S3a (Anhydride) FTIR spectra of polymers in anhydride form prior to hydrolysis, including Fwd SMAnh, Rev Sty, Rev SMAnh and Tri SMAnh. Figure S3b (Acid) FTIR spectra of polymers in acid form post hydrolysis, including Fwd SMA, Rev SMA and Tri SMA. Figure S4 (DSC) DSC curves for Fwd SMA under heat-cool-heat cycle and repeated linear heat ramp. Figure S5 (UV-vis) Raw and normalised UV-vis spectra of Fwd SMA, Rev SMA and Tri SMA. Table S5 (Surface Tension) Averaging of interfacial surface tension estimates from video captures of hanging pendant drop of SMA aggregate suspensions (1.65% wt.) in 50 mM PBS (0.2 M NaCl), with representative stills. Table S6 (Zeta Potential) Averaging of aggregate suspension zeta potential from DLS traces.