Dataset for "Antimicrobial Releasing Hydrogel Forming Microneedles"

This dataset pertains to a study involving the use of 3D printed microneedles (MNs) to form hydrogel-forming MNs (HFMs) for the delivery of antibiotics (amoxicillin and vancomycin) transdermally. It includes:

- the HFMs ability to swell in fluids over time rapidly and take up drugs in solution as a result (including characterisation of the HFMs and drug loaded-HFMs);
- the mechanical properties and skin penetration of both HFMs and Drug-loaded HFMs;
- the drug release profiles of the drug-loaded HFMs and how to control the release;
- the antimicrobial properties of the antibiotic HFMs against susceptible bacteria.

The data provides a suggestion towards the use of HFMs for the effective transdermal delivery of antibiotics, towards reducing the rate of antimicrobial resistance increase.

Subjects:
Bioengineering
Chemical synthesis

Cite this dataset as:
Turner, J., Laabei, M., Li, S., Estrela, P., Leese, H., 2023. Dataset for "Antimicrobial Releasing Hydrogel Forming Microneedles". Bath: University of Bath Research Data Archive. Available from: https://doi.org/10.15125/BATH-01176.

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Data

Data.zip
application/zip (5MB)
Creative Commons: Attribution 4.0

Creators

Joe Turner
Data Collector
University of Bath

Maisem Laabei
Data Collector
University of Bath

Shuxian Li
Data Collector
University of Bath

Pedro Estrela
Supervisor
University of Bath

Hannah Leese
Supervisor
University of Bath

Contributors

University of Bath
Rights Holder

Documentation

Data collection method:

Antimicrobial Properties: Disk Diffusion Assays using E.coli and S.aureus. Samples incuated for 24 hours. Optically monitored the area of inhibition surrounding the HFMs. Data provided are images, analysed using ImageJ with data saved in text file. Drug Release: Drug loaded HFMs were submerged in PBS. PBS samples were taken over time and UV-Vis analysis was used to calculate the concentration of drug that has been release. Data is in the form of Excel document. Mechanical properties: HFMs were tested on a DMA up to 10 newtons. Data is proved in the form of Excel document. Skin Penetration: HFMs were placed on porcine skin and a known force was applied and the resultant skin pores were optically imaged. Data is in the form of images. Swelling: HFMs were submerged in PBS. The mass of the HFMs was taken at various time points. The data provided is in the form of an Excel file. Raw data and data analysis can been found in the respective files.

Technical details and requirements:

The data is provided in MS Excel format.

Funders

Engineering and Physical Sciences Research Council (EPSRC)
https://doi.org/10.13039/501100000266

Minimally Invasive Molecularly Imprinted Conductive Nanoneedle Sensors
EP/V010859/1

Grant
RSG\R1\201185

Abbott Diabetes Care
https://doi.org/10.13039/100011946

Grant
2283996

Publication details

Publication date: 23 May 2023
by: University of Bath

Version: 1

DOI: https://doi.org/10.15125/BATH-01176

URL for this record: https://researchdata.bath.ac.uk/id/eprint/1176

Related papers and books

Turner, J. G., Laabei, M., Li, S., Estrela, P., and Leese, H. S., 2023. Antimicrobial releasing hydrogel forming microneedles. Biomaterials Advances, 151, 213467. Available from: https://doi.org/10.1016/j.bioadv.2023.213467.

Contact information

Please contact the Research Data Service in the first instance for all matters concerning this item.

Contact person: Joe Turner

Departments:

Faculty of Engineering & Design
Chemical Engineering
Electronic & Electrical Engineering

Life Sciences
Biology & Biochemistry

Research Centres & Institutes
Centre for Biosensors, Bioelectronics and Biodevices (C3Bio)