Dataset for 'An in-situ infection detection sensor coating for urinary catheters'


Milo, S., Thet, N., Liu, D., Nzakizwanayo, J., Jones, B., Jenkins, T., 2017. Dataset for 'An in-situ infection detection sensor coating for urinary catheters'. University of Bath. https://doi.org/10.15125/BATH-00429.


Dataset abstract

We describe a novel infection-responsive coating for urinary catheters that provides a clear visual early warning of Proteus mirabilis infection and subsequent blockage. The crystalline biofilms of P. mirabilis can cause serious complications for patients undergoing long-term bladder catheterisation. Healthy urine is around pH 6, bacterial urease increases urine pH leading to the precipitation of calcium and magnesium deposits from the urine, resulting in dense crystalline biofilms on the catheter surface that blocks urine flow. The coating is a dual layered system in which the lower poly(vinyl alcohol) layer contains the self-quenching dye carboxyfluorescein. This is capped by an upper layer of the pH responsive polymer poly(methyl methacrylate-co-methacrylic acid) (Eudragit S100®). Elevation of urinary pH (>pH 7) dissolves the Eudragit layer, releasing the dye to provide a clear visual warning of impending blockage. This dataset present raw data from the trial of the prototype catheter coatings within the in vitro bladder model system. The data presented details the change in bacterial biomass within residual bladder urine over time, as well as the consequent changes in urine pH and fluorescence output as a result of coating dissolution.

Title: Dataset for 'An in-situ infection detection sensor coating for urinary catheters'
Subjects: Medical and health interface > Biomaterials
Medical and health interface > Medical Instrumentation, Devices and Equipment
Medical and health interface > Medical science and disease
Microbial sciences > Microbiology
Departments: Faculty of Science > Chemistry
DOI: https://doi.org/10.15125/BATH-00429
URI: https://researchdata.bath.ac.uk/id/eprint/429
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