Single molecule experimental data for unphosphorylated Aurora-A measurements in Gilburt et al, Chemical Science 2019

Single molecule experimental data for unphosphorylated Aurora-A measurements in Gilburt et al, Chemical Science 2019

Raw and partially processed data for the dwell time histogram in the following publication: James A H Gilburt, Paul Girvan, Julian Blagg, Liming Ying, Charlotte A Dodson (2019) Ligand discrimination between active and inactive activation loop conformations of Aurora-A kinase is unmodified by phosphorylation. Chemical Science.

Keywords:
Protein kinase, Activation loop, Single molecule fluorescence, TIRF microscopy
Subjects:
Biomolecules and biochemistry
Chemical synthesis

Cite this dataset as:
Dodson, C., Gilburt, J., Ying, L., 2019. Single molecule experimental data for unphosphorylated Aurora-A measurements in Gilburt et al, Chemical Science 2019. Zenodo. https://doi.org/10.5281/zenodo.2555379.

Export

Creators

James Gilburt
Imperial College London

Liming Ying
Imperial College London

Funders

Imperial College London
https://doi.org/10.13039/501100000761

Using single molecule spectroscopy to inform drug discovery in protein kinases

Biotechnology and Biological Sciences Research Council (BBSRC)
https://doi.org/10.13039/501100000268

Conformational selection in Aurora-A kinase: competition between activator- and inhibitor- promoted forms
BB/M021149/1

Value in People Award

AstraZeneca-Imperial College Innovation Fund

The effect of clinical mutations and kinase ligands on conformation and dynamics of protein kinase drug targets

Publication details

Publication date: 7 March 2019
by: Zenodo

Version: 1

DOI: https://doi.org/10.5281/zenodo.2555379

URL for this record: https://researchdata.bath.ac.uk/id/eprint/617

Related articles

Gilburt, J. A. H., Girvan, P., Blagg, J., Ying, L. and Dodson, C. A., 2019. Ligand discrimination between active and inactive activation loop conformations of Aurora-A kinase is unmodified by phosphorylation. Chemical Science, 10(14), pp.4069-4076. Available from: https://doi.org/10.1039/C8SC03669A.

Contact information

Please contact the Research Data Service in the first instance for all matters concerning this item.

Contact person: Charlotte Dodson

Departments:

Faculty of Science
Pharmacy & Pharmacology

Research Centres & Institutes
Centre for Therapeutic Innovation