Single molecule experimental data for unphosphorylated Aurora-A measurements in Gilburt et al, Chemical Science 2019

Raw and partially processed data for the dwell time histogram in the following publication: James A H Gilburt, Paul Girvan, Julian Blagg, Liming Ying, Charlotte A Dodson (2019) Ligand discrimination between active and inactive activation loop conformations of Aurora-A kinase is unmodified by phosphorylation. Chemical Science.

Keywords:
Protein kinase, Activation loop, Single molecule fluorescence, TIRF microscopy
Subjects:
Biomolecules and biochemistry
Chemical synthesis

Cite this dataset as:
Dodson, C., Gilburt, J., Ying, L., 2019. Single molecule experimental data for unphosphorylated Aurora-A measurements in Gilburt et al, Chemical Science 2019. Zenodo. Available from: https://doi.org/10.5281/zenodo.2555379.

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Creators

James Gilburt
Imperial College London

Liming Ying
Imperial College London

Contributors

University of Bath
Rights Holder

Funders

Imperial College London
https://doi.org/10.13039/501100000761

Imperial College Junior Research Fellowship – Using single molecule spectroscopy to inform drug discovery in protein kinases

Biotechnology and Biological Sciences Research Council
https://doi.org/10.13039/501100000268

Conformational selection in Aurora-A kinase: competition between activator- and inhibitor- promoted forms
BB/M021149/1

Value in People Award (Charlotte Dodson)

Imperial College London
https://doi.org/10.13039/501100000761

AstraZeneca Innovation Fund award

Publication details

Publication date: 7 March 2019
by: Zenodo

Version: 1

DOI: https://doi.org/10.5281/zenodo.2555379

URL for this record: https://researchdata.bath.ac.uk/id/eprint/617

Related papers and books

Gilburt, J. A. H., Girvan, P., Blagg, J., Ying, L., and Dodson, C. A., 2019. Ligand discrimination between active and inactive activation loop conformations of Aurora-A kinase is unmodified by phosphorylation. Chemical Science, 10(14), 4069-4076. Available from: https://doi.org/10.1039/c8sc03669a.

Contact information

Please contact the Research Data Service in the first instance for all matters concerning this item.

Contact person: Charlotte Dodson

Departments:

Life Sciences
Pharmacy & Pharmacology

Research Centres & Institutes
Centre for Therapeutic Innovation