Dataset for "Molecular Adaptations of Adipose Tissue to 6 weeks of Morning Fasting vs Daily Breakfast Consumption in Lean and Obese Adults"
This study assessed molecular responses of human subcutaneous abdominal adipose tissue (SCAT) to 6 weeks of morning fasting. Forty-nine healthy lean (n = 29) and obese (n = 20) adults provided SCAT biopsies before and after 6 weeks of morning fasting (FAST; 0 kcal until 12.00 h) or daily breakfast consumption (BFAST; ≥700 kcal before 11.00 h). Biopsies were analysed for mRNA levels of selected genes, and GLUT4 and Akt protein content. This dataset includes individual participant data for the following outcome measures: Adipose tissue mRNA expression of genes involved in insulin signalling, AMPK signalling, circadian rhythms, lipid metabolism, glucose metabolism, inflammation/cytokine signalling, and mitochondrial signalling; adipose tissue protein content of GLUT4, Akt1 and Akt2, basal and insulin-stimulated Akt phosphorylation, insulin-stimualted adipose tissue glucose uptake. This trial was registered as ISRCTN31521726.
Cite this dataset as:
Gonzalez, J.,
2017.
Dataset for "Molecular Adaptations of Adipose Tissue to 6 weeks of Morning Fasting vs Daily Breakfast Consumption in Lean and Obese Adults".
Bath: University of Bath Research Data Archive.
Available from: https://doi.org/10.15125/BATH-00446.
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Creators
Javier Gonzalez
University of Bath
Contributors
University of Bath
Rights Holder
Funders
Biotechnology and Biological Sciences Research Council
https://doi.org/10.13039/501100000268
Extended Daily Fasting (Omission of Breakfast) and the Regulation of Energy Balance
BB/H008322/1
Publication details
Publication date: 20 December 2017
by: University of Bath
Version: 1
DOI: https://doi.org/10.15125/BATH-00446
URL for this record: https://researchdata.bath.ac.uk/id/eprint/446
Related papers and books
Gonzalez, J. T., Richardson, J. D., Chowdhury, E. A., Koumanov, F., Holman, G. D., Cooper, S., Thompson, D., Tsintzas, K., and Betts, J. A., 2017. Molecular adaptations of adipose tissue to 6 weeks of morning fasting vs. daily breakfast consumption in lean and obese adults. The Journal of Physiology, 596(4), 609-622. Available from: https://doi.org/10.1113/jp275113.
Contact information
Please contact the Research Data Service in the first instance for all matters concerning this item.
Contact person: Javier Gonzalez
Faculty of Humanities & Social Sciences
Health
