Dataset for "Molecular Adaptations of Adipose Tissue to 6 weeks of Morning Fasting vs Daily Breakfast Consumption in Lean and Obese Adults"

Dataset for "Molecular Adaptations of Adipose Tissue to 6 weeks of Morning Fasting vs Daily Breakfast Consumption in Lean and Obese Adults"

This study assessed molecular responses of human subcutaneous abdominal adipose tissue (SCAT) to 6 weeks of morning fasting. Forty-nine healthy lean (n = 29) and obese (n = 20) adults provided SCAT biopsies before and after 6 weeks of morning fasting (FAST; 0 kcal until 12.00 h) or daily breakfast consumption (BFAST; ≥700 kcal before 11.00 h). Biopsies were analysed for mRNA levels of selected genes, and GLUT4 and Akt protein content. This dataset includes individual participant data for the following outcome measures: Adipose tissue mRNA expression of genes involved in insulin signalling, AMPK signalling, circadian rhythms, lipid metabolism, glucose metabolism, inflammation/cytokine signalling, and mitochondrial signalling; adipose tissue protein content of GLUT4, Akt1 and Akt2, basal and insulin-stimulated Akt phosphorylation, insulin-stimualted adipose tissue glucose uptake. This trial was registered as ISRCTN31521726.

Cite this dataset as:
Gonzalez, J., 2017. Dataset for "Molecular Adaptations of Adipose Tissue to 6 weeks of Morning Fasting vs Daily Breakfast Consumption in Lean and Obese Adults". University of Bath. https://doi.org/10.15125/BATH-00446.

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Creators

Javier Gonzalez
University of Bath

Documentation

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Funders

Biotechnology and Biological Sciences Research Council (BBSRC)
https://doi.org/10.13039/501100000268

Extended Daily Fasting (Omission of Breakfast) and the Regulation of Energy Balance
BB/H008322/1

Publication details

Publication date: 20 December 2017
by: University of Bath

Version: 1

DOI: https://doi.org/10.15125/BATH-00446

URL for this record: https://researchdata.bath.ac.uk/id/eprint/446

Related articles

Gonzalez, J. T., Richardson, J. D., Chowdhury, E. A., Koumanov, F., Holman, G. D., Cooper, S., Thompson, D., Tsintzas, K. and Betts, J. A., 2017. Molecular adaptations of adipose tissue to 6 weeks of morning fasting vs. daily breakfast consumption in lean and obese adults. The Journal of Physiology, 596(4), pp.609-622. Available from: https://doi.org/10.1113/JP275113.

Contact information

Please contact the Research Data Service in the first instance for all matters concerning this item.

Contact person: Javier Gonzalez

Departments:

Faculty of Humanities & Social Sciences
Health