Dataset for 'Pre-Exercise Breakfast Ingestion versus Extended Overnight Fasting Increases Postprandial Glucose Flux after Exercise in Healthy Men: Pre-exercise feeding and postprandial glucose flux'

Dataset for 'Pre-Exercise Breakfast Ingestion versus Extended Overnight Fasting Increases Postprandial Glucose Flux after Exercise in Healthy Men: Pre-exercise feeding and postprandial glucose flux'

The aim of this study was to characterise postprandial glucose flux after exercise in the fed versus overnight fasted-state and to investigate potential underlying mechanisms. In a randomized order, twelve men underwent breakfast-rest (BR; 3 h semi-recumbent), breakfast-exercise (BE; 2 h semi-recumbent before 60-min of cycling (50% peak power output) and overnight fasted-exercise (FE; as per BE omitting breakfast) trials. An oral glucose tolerance test (OGTT) was completed post-exercise (post-rest on BR). Dual stable isotope tracers ([U-13C] glucose ingestion and [6,6-2H2] glucose infusion) and muscle biopsies were combined to assess postprandial plasma glucose kinetics and intramuscular signaling, respectively. Plasma intestinal fatty acid binding (I-FABP) concentrations were determined as a marker of intestinal damage. The results from this study showed that consuming breakfast before exercise increases post-exercise postprandial plasma glucose disposal, which is offset (primarily) by increased appearance rates of orally-ingested glucose. Therefore, metabolic responses to fed-state exercise cannot be readily inferred from studies conducted in a fasted state.

Keywords:
Breakfast, Exercise, Insulin sensitivity, Glycemia, Metabolism
Subjects:
Biomolecules and biochemistry

Cite this dataset as:
Edinburgh, R., Hengist, A., Smith, H., Travers, R., Koumanov, F., Betts, J., Thompson, D., Walhin, J., Wallis, G., Hamilton, D., Stevenson, E., Tipton, K., Gonzalez, J., 2019. Dataset for 'Pre-Exercise Breakfast Ingestion versus Extended Overnight Fasting Increases Postprandial Glucose Flux after Exercise in Healthy Men: Pre-exercise feeding and postprandial glucose flux'. University of Bath Research Data Archive. https://doi.org/10.15125/BATH-00608.

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Data

AJP_Final%20Data.xlsx
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Creative Commons: Attribution 4.0

Creators

Rob Edinburgh
University of Bath

Aaron Hengist
University of Bath

Harry Smith
University of Bath

Rebecca Travers
University of Bath

James Betts
University of Bath

Dylan Thompson
University of Bath

Jean-Philippe Walhin
University of Bath

Gareth Wallis
University of Birmingham

D. Lee Hamilton
University of Stirling

Emma Stevenson
Newcastle University

Kevin Tipton
University of Stirling

Javier Gonzalez
University of Bath

Documentation

Data collection method:

Supplementary (individual participant) data are included in this data set for reported outcome measures.

Documentation Files

README_FILE_FOR_ARCHIVE.docx
application/vnd.openxmlformats-officedocument.wordprocessingml.document (21kB)
Creative Commons: Attribution 4.0

Funders

Medical Research Council (MRC)
https://doi.org/10.13039/501100000265

Role of Rab3 in Peripheral Tissue Insulin Resistance
MR/P002927/1

Rank Prize Funds

Fellowship for Javier Gonzalez - Understanding the Influence of Pre-Exercise Nutrition on PostPrandial Carbohydrate Metabolism and Energy Balance

European Society for Clinical Nutrition and Metabolism (ESPEN)
https://doi.org/10.13039/501100007743

ESPEN Research Fellowship for Javier Gonzalez - Using the Paradoxical Second-Meal Phenomenon to Gain Insight into the Molecular and Metabolic Regulation of Whole-Body Glucose Metabolism

Publication details

Publication date: 27 February 2019
by: University of Bath

Version: 1

DOI: https://doi.org/10.15125/BATH-00608

URL for this record: https://researchdata.bath.ac.uk/id/eprint/608

Related articles

Edinburgh, R. M., Hengist, A., Smith, H. A., Travers, R. L., Koumanov, F., Betts, J. A., Thompson, D., Walhin, J.-P., Wallis, G. A., Hamilton, D. L., Stevenson, E. J., Tipton, K. D. and Gonzalez, J. T., 2018. Preexercise breakfast ingestion versus extended overnight fasting increases postprandial glucose flux after exercise in healthy men. American Journal of Physiology-Endocrinology and Metabolism, 315(5), pp.E1062-E1074. Available from: https://doi.org/10.1152/ajpendo.00163.2018.

Contact information

Please contact the Research Data Service in the first instance for all matters concerning this item.

Contact person: Javier Gonzalez

Departments:

Faculty of Humanities & Social Sciences
Health