Dataset for “Ketogenic diet but not free-sugar restriction alters glucose tolerance, lipid metabolism, peripheral tissue phenotype, and gut microbiome: RCT”
The dataset includes demographic data of participants (n=60) randomised to one of three groups:
1. CONTROL (moderate sugar) - reflecting the composition of a typical European diet;
2. Low sugar - the same composition of a typical European diet but with <5% energy intake from sugar;
3. Low carbohydrate - low carbohydrate diet with <5% energy intake from sugar, replacing carbohydrate energy with fat.
All laboratory trials took place at the University of Bath. Participants consumed these diets for period of 12 weeks, with laboratory visits at baseline, at week 4, and at week 12.
The types of data that were collected during the trials are as follows:
- Height;
- Body mass;
- Body composition (by Dual-energy x-ray absorptiometry);
- Resting metabolic rate;
- Postprandial substrate oxidation;
- Exercise metabolism;
- Physical activity energy expenditure;
- Fasting and postprandial concentrations of circulating metabolites (e.g., glucose, lactate triacylglycerol) and hormones (e.g. insulin, C-peptide);
- Nuclear magnetic resonance spectroscopy measures of plasma (e.g., lipoprotein size and particle number);
- Skeletal muscle protein levels;
- Adipose tissue mRNA levels;
- Fasting haematology (e.g., white blood cell count, haematocrit, haemoglobin concentration);
- Urinary acetoacetate concentrations;
- Self-reported energy intake;
- Visual analogue scales for appetite and mood;
- Continuous glucose monitoring.
Cite this dataset as:
Gonzalez, J.,
2024.
Dataset for “Ketogenic diet but not free-sugar restriction alters glucose tolerance, lipid metabolism, peripheral tissue phenotype, and gut microbiome: RCT”.
Bath: University of Bath Research Data Archive.
Available from: https://doi.org/10.15125/BATH-01366.
Export
Data
Parallel RCT … data_03.07.2024.xlsx
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet (1MB)
Creative Commons: Attribution 4.0
Creators
Javier Gonzalez
University of Bath
Contributors
University of Bath
Rights Holder
Documentation
Methodology link:
Documentation Files
AH 12-week … reports_v3 copy.pdf
application/pdf (351kB)
Creative Commons: Attribution 4.0
Funders
Rank Prize Funds
PACSI Physical Activity and the Role of Sugar Intake
Cosun Nutrition Center
PACSI Physical Activity and the Role of Sugar Intake
University of Bath
https://doi.org/10.13039/501100000835
PACSI Physical Activity and the Role of Sugar Intake
Ian Tarr
PACSI Physical Activity and the Role of Sugar Intake
Medical Research Council (MRC)
https://doi.org/10.13039/501100000265
Role of Rab3 in Peripheral Tissue Insulin Resistance
MR/P002927/1
British Heart Foundation (BHF)
https://doi.org/10.13039/501100000274
Fellowship
FS/15/56/31645
British Heart Foundation (BHF)
https://doi.org/10.13039/501100000274
Fellowship
FS/SBSRF/21/31013
Publication details
Publication date: 5 August 2024
by: University of Bath
Version: 1
DOI: https://doi.org/10.15125/BATH-01366
URL for this record: https://researchdata.bath.ac.uk/1366
Related papers and books
Hengist, A., Davies, R. G., Walhin, J.-P., Buniam, J., Merrell, L. H., Rogers, L., Bradshaw, L., Moreno-Cabañas, A., Rogers, P. J., Brunstrom, J. M., Hodson, L., van Loon, L. J.C., Barton, W., O’Donovan, C., Crispie, F., O’Sullivan, O., Cotter, P. D., Proctor, K., Betts, J. A., Koumanov, F., Thompson, D., and Gonzalez, J. T., 2024. Ketogenic diet but not free-sugar restriction alters glucose tolerance, lipid metabolism, peripheral tissue phenotype, and gut microbiome: RCT. Cell Reports Medicine, 5(8), 101667. Available from: https://doi.org/10.1016/j.xcrm.2024.101667.
Contact information
Please contact the Research Data Service in the first instance for all matters concerning this item.
Contact person: Javier Gonzalez
Faculty of Humanities & Social Sciences
Health
Research Centres & Institutes
Centre for Nutrition, Exercise and Metabolism (CNEM)