Dataset for “Ketogenic diet but not free-sugar restriction alters glucose tolerance, lipid metabolism, peripheral tissue phenotype, and gut microbiome: RCT”

The dataset includes demographic data of participants (n=60) randomised to one of three groups:

1. CONTROL (moderate sugar) - reflecting the composition of a typical European diet;
2. Low sugar - the same composition of a typical European diet but with <5% energy intake from sugar;
3. Low carbohydrate - low carbohydrate diet with <5% energy intake from sugar, replacing carbohydrate energy with fat.

All laboratory trials took place at the University of Bath. Participants consumed these diets for period of 12 weeks, with laboratory visits at baseline, at week 4, and at week 12.

The types of data that were collected during the trials are as follows:

- Height;
- Body mass;
- Body composition (by Dual-energy x-ray absorptiometry);
- Resting metabolic rate;
- Postprandial substrate oxidation;
- Exercise metabolism;
- Physical activity energy expenditure;
- Fasting and postprandial concentrations of circulating metabolites (e.g., glucose, lactate triacylglycerol) and hormones (e.g. insulin, C-peptide);
- Nuclear magnetic resonance spectroscopy measures of plasma (e.g., lipoprotein size and particle number);
- Skeletal muscle protein levels;
- Adipose tissue mRNA levels;
- Fasting haematology (e.g., white blood cell count, haematocrit, haemoglobin concentration);
- Urinary acetoacetate concentrations;
- Self-reported energy intake;
- Visual analogue scales for appetite and mood;
- Continuous glucose monitoring.

Keywords:
Energy balance, Metabolism, Ketogenic, Sugar, Diet, Physical activity, Body fat, Energy intake, Lipoprotein
Subjects:
Food science and nutrition

Cite this dataset as:
Gonzalez, J., 2024. Dataset for “Ketogenic diet but not free-sugar restriction alters glucose tolerance, lipid metabolism, peripheral tissue phenotype, and gut microbiome: RCT”. Bath: University of Bath Research Data Archive. Available from: https://doi.org/10.15125/BATH-01366.

Export

Data

Parallel RCT … data_03.07.2024.xlsx
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet (1MB)
Creative Commons: Attribution 4.0

Creators

Contributors

University of Bath
Rights Holder

Documentation

Documentation Files

AH 12-week … reports_v3 copy.pdf
application/pdf (351kB)
Creative Commons: Attribution 4.0

Funders

Rank Prize Funds

PACSI Physical Activity and the Role of Sugar Intake

Cosun Nutrition Center

PACSI Physical Activity and the Role of Sugar Intake

PACSI Physical Activity and the Role of Sugar Intake

Ian Tarr

PACSI Physical Activity and the Role of Sugar Intake

Medical Research Council (MRC)
https://doi.org/10.13039/501100000265

Role of Rab3 in Peripheral Tissue Insulin Resistance
MR/P002927/1

British Heart Foundation (BHF)
https://doi.org/10.13039/501100000274

Fellowship
FS/15/56/31645

British Heart Foundation (BHF)
https://doi.org/10.13039/501100000274

Fellowship
FS/SBSRF/21/31013

Publication details

Publication date: 5 August 2024
by: University of Bath

Version: 1

DOI: https://doi.org/10.15125/BATH-01366

URL for this record: https://researchdata.bath.ac.uk/1366

Related papers and books

Hengist, A., Davies, R. G., Walhin, J.-P., Buniam, J., Merrell, L. H., Rogers, L., Bradshaw, L., Moreno-Cabañas, A., Rogers, P. J., Brunstrom, J. M., Hodson, L., van Loon, L. J.C., Barton, W., O’Donovan, C., Crispie, F., O’Sullivan, O., Cotter, P. D., Proctor, K., Betts, J. A., Koumanov, F., Thompson, D., and Gonzalez, J. T., 2024. Ketogenic diet but not free-sugar restriction alters glucose tolerance, lipid metabolism, peripheral tissue phenotype, and gut microbiome: RCT. Cell Reports Medicine, 5(8), 101667. Available from: https://doi.org/10.1016/j.xcrm.2024.101667.

Contact information

Please contact the Research Data Service in the first instance for all matters concerning this item.

Contact person: Javier Gonzalez

Departments:

Faculty of Humanities & Social Sciences
Health

Research Centres & Institutes
Centre for Nutrition, Exercise and Metabolism (CNEM)