Dataset for "Lipid metabolism links nutrient-exercise timing to insulin sensitivity in overweight men"
The aim of the present work was to assess the acute and chronic effects of manipulating nutrient-exercise timing on lipid metabolism, skeletal muscle adaptation, and oral glucose insulin sensitivity in overweight and obese men. This project comprised two experiments. We first assessed the acute metabolic and mRNA responses to manipulating nutrient-exercise timing (Acute Study), followed by a 6-week randomized controlled trial to assess the longer-term adaptations in response to nutrient-exercise timing (Training Study). We showed that in overweight/obese, but otherwise healthy men (mean±SD for age: 30 ± 10 years for acute study, 35 ± 9 years for training study and BMI: 30.2±3.5 kg/m-2 for acute study, 30.9±4.5 kg/m-2 for training study) a single exercise bout before versus after nutrient provision increased lipid utilization at the whole-body level, but also in both type I (p<0.01) and type II muscle fibers (p=0.02). We then used a 6-week intervention to show sustained, 2-fold increases in lipid utilization with exercise training before versus after nutrient provision (p<0.01). An oral glucose-derived estimate of peripheral insulin sensitivity (OGIS index) increased when training was performed before versus after nutrient provision (25±38 vs -21±32 mL/min/m-2; p=0.01) and this was associated with increased lipid utilization during exercise (r=0.50, p=0.02). Regular exercise prior to nutrient provision augmented remodelling of skeletal muscle phospholipids and muscle expression of the glucose transport protein GLUT4 (p<0.05). These responses were observed despite similar changes in body mass, waist-to-hip ratio, and oxidative capacity. Therefore: 1) experiments investigating exercise training and metabolic health need to control for nutrient-exercise timing; 2) exercise performed before versus after nutrient intake may exert beneficial effects on lipid utilization and oral glucose insulin sensitivity.
Cite this dataset as:
Edinburgh, R.,
Bradley, H.,
Abdullah, N.,
Robinson, S.,
Chrzanowski-Smith, O.,
Walhin, J.,
Joanisse, S.,
Manolopoulos, K.,
Philp, A.,
Hengist, A.,
Chabowski, A.,
Brodsky, F.,
Koumanov, F.,
Betts, J.,
Thompson, D.,
Wallis, G.,
Gonzalez, J.,
2019.
Dataset for "Lipid metabolism links nutrient-exercise timing to insulin sensitivity in overweight men".
Bath: University of Bath Research Data Archive.
Available from: https://doi.org/10.15125/BATH-00672.
Export
Data
Data.xlsx
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet (108kB)
Creative Commons: Attribution 4.0
Supplementary (individual participant) data are included in this data set for reported outcome measures.
Creators
Rob Edinburgh
University of Bath
Helen Bradley
University of Birmingham
Nurul Abdullah
University of Birmingham
Scott Robinson
University of Birmingham
Oliver Chrzanowski-Smith
University of Bath
Jean-Philippe Walhin
University of Bath
Sophie Joanisse
University of Birmingham
Konstantinos Manolopoulos
University of Birmingham
Andrew Philp
Garvan Institute of Medical Research
Aaron Hengist
University of Bath
Adrian Chabowski
Medical University of Białystok
Frances Brodsky
University College London
Francoise Koumanov
University of Bath
James Betts
University of Bath
Dylan Thompson
University of Bath
Gareth Wallis
University of Birmingham
Javier Gonzalez
University of Bath
Contributors
University of Bath
Rights Holder
Documentation
Data collection method:
Supplementary (individual participant) data are included in this data set for reported outcome measures. Detailed data collection methods are included in the documentation (readme) file.
Documentation Files
Read_me_file_for_archive.docx
application/vnd.openxmlformats-officedocument.wordprocessingml.document (24kB)
Creative Commons: Attribution 4.0
This document contains information regarding the methods used to collect the data provided in the excel data sheet.
Supplementary … and_Tables.docx
application/vnd.openxmlformats-officedocument.wordprocessingml.document (34kB)
Creative Commons: Attribution 4.0
Funders
Physiological Society
https://doi.org/10.13039/501100000674
Can Exercise in the Fasted State Unlock Metabolic Health Benefits for Overweight and Obese Individuals
Allen Foundation
https://doi.org/10.13039/100008796
Medical Research Council
https://doi.org/10.13039/501100000265
Role of Rab3 in Peripheral Tissue Insulin Resistance
MR/P002927/1
Medical Research Council
https://doi.org/10.13039/501100000265
Regulation of Human Glucose Homeostasis by the Novel CHC22 Clathrin Isoform
MR/S008144/1
Rank Prize Funds
Fellowship for Javier Gonzalez - Understanding the Influence of Pre-Exercise Nutrition on PostPrandial Carbohydrate Metabolism and Energy Balance
European Society for Clinical Nutrition and Metabolism
https://doi.org/10.13039/501100007743
ESPEN Research Fellowship for Javier Gonzalez - Using the Paradoxical Second-Meal Phenomenon to Gain Insight into the Molecular and Metabolic Regulation of Whole-Body Glucose Metabolism
Publication details
Publication date: 19 October 2019
by: University of Bath
Version: 1
DOI: https://doi.org/10.15125/BATH-00672
URL for this record: https://researchdata.bath.ac.uk/id/eprint/672
Related papers and books
Edinburgh, R. M., Bradley, H. E., Abdullah, N.-F., Robinson, S. L., Chrzanowski-Smith, O. J., Walhin, J.-P., Joanisse, S., Manolopoulos, K. N., Philp, A., Hengist, A., Chabowski, A., Brodsky, F. M., Koumanov, F., Betts, J. A., Thompson, D., Wallis, G. A., and Gonzalez, J. T., 2019. Lipid Metabolism Links Nutrient-Exercise Timing to Insulin Sensitivity in Men Classified as Overweight or Obese. The Journal of Clinical Endocrinology & Metabolism, 105(3), 660-676. Available from: https://doi.org/10.1210/clinem/dgz104.
Contact information
Please contact the Research Data Service in the first instance for all matters concerning this item.
Contact person: Rob Edinburgh
Faculty of Humanities & Social Sciences
Health
